Understanding RNA polymerase (RNAP) structure and function is a key to understanding gene expression in molecular detail. The long-term objective of our research is to uncover the molecular basis of transcription mechanism and regulation through structure-functional analysis of bacterial RNAP and associated proteins. In addition, we use bacteriophage development as a model system to study temporal regulation of gene expression and to uncover novel mechanisms of transcription regulation. We also study microcins, small ribosomally-synthesized inhibitors of bacterial growth.
Konstantin Severinov, Ph.D., D.Sc., is Professor of Molecular Biology and Biochemistry at Rutgers University, New Brunswick. He also heads research laboratories in the Russian Academy of Sciences Institutes of Molecular Genetics and Gene Biology in Moscow. He is a Fellow of the American Academy of Microbiology, a Senior Fulbright Scholar, and a member of the Scientific Council of Russian State Corporation Rusnano. Scientific interests include the mechanisms of gene expression in bacteria and development of new antibiotics. Dr. Severinov authored and co-authored more than 170 research papers in top scientific journals and holds six international patents.
Konstantin works on genetic, biochemical, and structural analyses of transcription mechanism and regulation in bacteria. He also studies the regulation of macromolecular synthesis during the process of bacteriophage infection and various molecular interactions between bacteriophages and their host bacteria. Another main direction of his research involves analysis of antibacterial peptides called microcins: their structures, mechanisms of function, evolution, and the use as new antibiotics.