Meiosis is the process by which the chromosome number is divided precisely in half. When defects occur in the meiotic process the oocyte or sperm receives an abnormal number of chromosomes (aneuploidy). Aneuploidy is usually catastrophic and is the leading cause of infertility in women and the cause of disorders such as Down’s syndrome. Research in my laboratory is directed towards understanding meiosis in the model organism Drosophila melanogaster. By utilizing the experimental benefits of Drosophila, mutations that disrupt various steps in the meiotic program can be isolated and characterized. Currently, the lab focuses on two of the most important aspects of meiosis: i) the repair of programmed double strand breaks (DSB) in the DNA into crossovers, and ii) the involvement of crossovers in the segregation of homologous chromosomes.
Kim McKim is a Principal Investigator at the Waksman Institute and Professor of Genetics in the School of Arts and Science. Professor McKim uses the fruit fly Drosophila melanogaster to study the fundamental mechanisms of heredity. His lab uses molecular genetics, cell biology and genomic approaches to identify and characterize genes that are important for reproductive fitness, including the segregation of chromosomes during meiosis and other processes that lead to the the generation of a healthy oocyte.
Complete list of publications here
Janet Jang McKim
Lin Ing Wang