The Irvine Lab investigates intercellular signaling networks and the influence of these signaling networks on cell fate, organ growth, and morphogenesis, using both Drosophila and mammalian models. We study both the molecular mechanisms of signal transduction, and the roles of signaling pathways in different developmental and physiological contexts. A current focus is on how cells perceive their mechanical environment, and how tissue mechanics influences organ growth and morphogenesis. We also investigate relationships between spatial patterning and growth in developing and regenerating organs and how patterning inputs are integrated with other factors that influence organ growth, including tissue mechanics.
Organization and Function of Tension-dependent Complexes at Adherens Junctions.
Rauskolb, C., Cervantes, E., Madere, F. and Irvine, K.D. 2019. J Cell Science, 132, jcs224063.
Early girl is a novel component of the Fat signaling pathway.
Misra, J.R. and Irvine, K.D. 2019. PLoS Genetics, 15, e1007955.
Oriented cell divisions are not required for Drosophila wing shape.
Zhou, Z. Alégot, H., and Irvine, K.D. 2019. Current Biology, 29, 856-864.
Recruitment of Jub by a-catenin promotes Yki activity and Drosophila wing growth.
Alégot, H., Markosian, C., Rauskolb, C. Yang, J., Kirichenko, E., Wang, Y.-C., and Irvine, K.D. 2019. J Cell Science, 132, jcs222018.
The Dynamics of Hippo Signaling during Drosophila Wing.
Pan, Y., Alégot, H., Rauskolb, C. and Irvine, K.D. 2018. Development, 145, dev165712.
Tension-dependent regulation of mammalian Hippo signaling through LIMD1.
Ibar, C., Kirichenko, E., Keepers, B., Enners, E., Fleisch K. and Irvine, K.D. 2018. J Cell Science, 131, jcs214700.
Vamana couples Fat signaling to the Hippo pathway.
Misra, J.R. and Irvine, K.D. 2016. Dev. Cell 39, 254-266. PMCID: PMC5102026
Differential growth triggers mechanical feedback that elevates Hippo signaling.
Pan, Y., Heemskerk, I., Ibar, C., Shraiman, B. I. and Irvine, K.D. 2016. Proc. Nat. Acad. Sci. USA 113, E6974-E6983 PMCID: PMC5111668
Localization of Hippo Signaling complexes and Warts activation in vivo.
Sun, S., Reddy, B.V.V.G., and Irvine, K.D. 2015. Nature Communications 6, 8402. PMCID: PMC4598633
Coordination of planar cell polarity pathways through Spiny legs.
Ambegaonkar, A.A. and Irvine, K.D. 2015. eLife 4, e09946. PMCID: PMC4764577
Cytoskeletal Tension inhibits Hippo signaling through an Ajuba-Warts complex.
Rauskolb, C., Sun, S., Sun, G., Pan, Y. and Irvine, K.D. 2014. Cell, 158, 143-156. PMCID: PMC4082802
Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling.
Codelia, V., Sun, G., and Irvine, K.D. 2014. Current Biology, 24, 2012-2017. PMCID: PMC4160395
Ajuba family proteins link JNK to Hippo signaling. Science Signaling 6, ra81.
Sun, G. and Irvine, K.D. 2013. PMCID: PMC3830546
Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins.
Reddy, B.V.V.G. and Irvine, K.D. 2013. Dev. Cell 24, 459-471. PMCID: PMC3624988
Propagation of Dachsous-Fat Planar Cell Polarity.
Ambegaonkar, A.A., Pan, G., Mani, M., Feng, Y. and Irvine, K.D. 2012. Current Biology 22, 1302-1308. PMCID: PMC3418676
Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.
Mao, Y., Mulvaney, J., Zakaria, S., Yu, T., Malanga, K., Allen, S., Basson, M.A., Francis-West, P., and Irvine, K.D. 2011. Development, 138, 947-957. PMCID: PMC3035097
Modulation of Fat-Dachsous binding by the cadherin domain kinase Four-jointed.
Simon, M.A., Xu, A., Ishikawa, H.O. and Irvine, K.D. 2010. Current Biology 20, 811-817. PMCID: PMC2884055
Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation.
Staley, B.K. and Irvine, K.D. 2010. Current Biology 20, 1580-1587. PMCID: PMC2955330
Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains.
Ishikawa, H.O., Takeuchi, H., Haltiwanger, R.S. and Irvine, K.D. 2008. Science 321, 401-404. PMCID: PMC2562711
Delineation of a Fat tumor suppressor pathway.
Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R., and Irvine, K.D. 2006. Nature Genetics 38, 1142-1150.
Kenneth Irvine is Principal Investigator in the Waksman Institute, Distinguished Professor in the Department of Molecular Biology and Biochemistry, and Director of the Graduate Program in Cell and Developmental Biology. He studies intercellular signaling networks and the influence of these signaling networks on cell fate, organ growth, and morphogenesis, using both Drosophila and mammalian models. A current focus in his lab is on how cells perceive their mechanical environment, and how tissue mechanics influences organ growth and morphogenesis.