Richard H. Ebright--Patents

Issued Patents

Ebright, R., Ebright, Y., and Pendergrast, P.S. (1996) CAP-phenanthroline conjugate for DNA cleavage. US Patent 5,556,949.

Seul, M. and Ebright, R. (2003) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. Australian Patent 756,945.

Ebright, R. and Ebright, Y. (2005) Bis-transition-metal-chelate probes. US Patent 6,919,333.

Seul, M. and Ebright, R. (2006) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. US Patent 7,083,914.

Ebright, R. and Ebright, Y. (2006) Reagents and procedures for high-specificity labelling. US Patent 7,141,655.

Ebright, R. and Ebright, Y. (2007) Ultra-high-specificity fluorescent labelling. US Patent 7,282,373.

Seul, M. and Ebright, R. (2007) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. European Patent 1,003,904.

Ebright, R. and Ebright, Y. (2008) Bis-transition-metal-chelate probes. US Patent 7,371,745.

Ebright, R. and Ebright, Y. (2008) Reagents and procedures for multi-label high-specificity labelling. US Patent 7,381,572.

Severinov, K., Ebright, R, Pavlova, O., and Sineva, E. (2008) Mutational derivatives of peptide antibiotic microcin J25. US Patent 7,442,762. 

Seul, M. and Ebright, R. (2009) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. Japanese Patent 4,302,780.

Ebright, R. (2012) Switch region: target and method for inhibition of bacterial RNA polymerase. US Patent 8,114,583.

Ebright, R. (2012) Target and method for inhibition of bacterial RNA polymerase. US Patent 8,198,021.

Ebright, R. (2012) RNA exit channel: target and method for inhibition of bacterial RNA polymerase. US Patent 8,206,898.

Seul, M. and Ebright, R. (2013) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. Canadian Patent 2,291,853.

Ebright, R., Mukhopadhyay, J., Severinov, K., and Semenova, E.  (2013) Non-MccJ25-related lariat-peptide inhibitors of bacterial RNA polymerase. US Patent 8,354,246.

Ebright, R. and Wang, D. (2013) Bipartite inhibitors of bacterial RNA polymerase. US Patent 8,372,839.

Ebright, R., and Severinov, K. (2013)  Nucleic acid sequences for biosynthesis of non-MccJ25-related lariat peptides. US Patent 8,461,314.

Ebright, R. (2013) Target and method for inhibition of bacterial RNA polymerase. US Patent 8,575,306.

Ebright, R. (2014) RNA exit channel: target and method for inhibition of bacterial RNA polymerase. US Patent 8,697,354.

Ebright, R.  (2014) Arylpropionyl-alpha-pyrone antibacterial agents. US Patent 8,772,332.

Ebright, R., Degen, D., and Ebright, K. (2015) Bridge-helix cap: target and method for inhibition of bacterial RNA polymerase. US Patent 9,060,970.

Ebright, R. and Ebright, Y. (2015) Antibacterial agents: high-potency myxopyronin derivatives. US Patent 9,133,155.

Ebright, R. and Ebright, Y. (2015) Antibacterial agents: side-chain-fluorinated myxopyronin derivatives. US Patent 9,187,446.

Ebright, R., Ebright, Y., Feng, Y., and Degen, D. (2015) Antibacterial agents: salinamide derivatives. US Patent 9,221,880.

Ebright, R., Feng, Y., and Zhang, Y. (2016) Bipartite inhibitors of bacterial RNA polymerase: Sal-target-inhibitor/nucleoside-analog-inhibitor conjugates. US Patent 9,243,039.

Ebright, R., Ebright, Y., Shen, J., Bacci, J., Hiebel, A.-C., Solvible, W., Self, C., and Olson, G. (2016) Antibacterial agents: aryl myxopyronin derivatives. US Patent 9,315,495.

Ebright, R., Degen, D., Zhang, Y., Ebright, Y. (2016) Bipartite inhibitors of bacterial RNA polymerase. US Patent 9,415,112.

Ebright, R. and Shen, J. (2016) Antibacterial agents: phloroglucinol derivatives. US Patent 9,517,994.

Ebright, R., Ebright, Y., Shen, J., Bacci, J., Hiebel, A.-C., Solvible, W., Self, C., and Olson, G. (2017) Antibacterial agents: aryl myxopyronin derivatives. US Patent 9,592,221.

Ebright, R., Ebright, Y., Feng, Y., and Degen, D.  (2017) Antibacterial agents: salinamide derivatives. US Patent 9,605,028.

Ebright, R., Ebright, Y., Feng, Y., and Degen, D.  (2017) Antibacterial agents: salinamide derivatives. US Patent 9,809,626.

Ebright, R.  (2017) Antibacterial agents: combination of a rifamycin and a switch region inhibitor. US Patent 9,839,634.

Ebright, R., Ebright Y., Mandal, S., Wilde, R., and Li, S. (2018) Antibacterial agents: N(alpha)-aroyl-N-aryl-phenylalaninamides.  US Patent 9,919,998

Ebright, R. (2018) Color-encoding and in-situ interrogation of matrix-coupled chemical compounds. US Patent 9,945,051.

Ebright, R., Degen, D., Zhang, Y., Ebright, Y.  (2018) Bipartite inhibitors of bacterial RNA polymerase. US Patent 10,010,619.

Ebright, R., Ebright, Y., Shen, J., Bacci, J., Hiebel, A.-C., Solvible, W., Self, C., and Olson, G.  (2018) Antibacterial agents: aryl myxopyronin derivatives. European Patent EP2,861,570.

Ebright, R., Freundlich, J., Mittal, N., Jaskowski, M, and Shen, J.  (2019) Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols. US Patent US10450292.

Ebright, R. and Shen, J. (2020) Arylpropionyl-triketone antibacterial agents. US Patent 10800725.

Ebright, R., Ebright, Y., and Lin, C.-T. (2022) Antibacterial agents: dual-targeted RNA polymerase inhibitors. US Patent 11447502.

Ebright, R., Ebright, Y., Mandal, S., Wilde, R., and Li, S. (2022) Antibacterial agents: N(alpha)-aroyl-N-aryl-phenylalaninamides. European Patent EP3102193.

Ebright, R., Ebright, Y., Freundlich, J., Gallardo-Macia, R., and Li, S.-G. (2023)Antibacterial agents: arylalkylcarboxamido phloroglucinols. US Patent US11572337.

Ebright, R. and Ebright, Y. (2023) Antibacterial agents: O-alkyl-deuterated pyronins. US Patent US11685723.

Pending Patents

Ebright, R. and Ebright, Y. Antibacterial agents: soluble salts and aqueous formulations of pyronins. US20210002266 (filed 02/12/19).

Ebright, R. and Ebright, Y. Antibacterial agents: soluble salts and aqueous formulations of pyronins. EP3752142 (filed 02/12/19).

Ebright, R. and Ebright, Y. Antibacterial agents: O-alkyl-deuterated pyronins. EP3752143 (filed 02/12/19).

Ebright, R., Ebright, Y., and Lin, C.-T. Antibacterial agents: dual-targeted RNA polymerase inhibitors. EP3801494 (filed 05/23/19).

Ebright, R. and Ebright, Y. Antibacterial agents: dual-targeted RNA polymerase inhibitors: conjugates of benzoxazino- and spiro-rifamycins with Na-aroyl-N-aryl-phenylalaninamides. PCT/US22/40964 (filed 08/19/22).