Mutation in the seed storage protein kafirin creates a high-value food trait in sorghum

Wu, Y, Yuan L, Guo X, Holding DR, Messing J.  2013.  

Journal:

Nat Commun

Volume Number:

4

Pages:

2217

Abstract:

Sustainable food production for the earth's fast-growing population is a major challenge for breeding new high-yielding crops, but enhancing the nutritional quality of staple crops can potentially offset limitations associated with yield increases. Sorghum has immense value as a staple food item for humans in Africa, but it is poorly digested. Although a mutant exhibiting high-protein digestibility and lysine content has market potential, the molecular nature of the mutation is previously unknown. Here, building on knowledge from maize mutants, we take a direct approach and find that the high-digestible sorghum phenotype is tightly linked to a single-point mutation, rendering the signal peptide of a seed storage protein kafirin resistant to processing, indirectly reducing lysine-poor kafirins and thereby increasing lysine-rich proteins in the seeds. These findings indicate that a molecular marker can be used to accelerate introduction of this high nutrition and digestibility trait into different sorghum varieties.

Notes:

Wu, YongruiYuan, LinglingGuo, XiaomeiHolding, David RMessing, JoachimengResearch Support, Non-U.S. Gov'tEngland2013/08/21 06:00Nat Commun. 2013;4:2217. doi: 10.1038/ncomms3217.

Related External URL:

http://www.ncbi.nlm.nih.gov/pubmed/23948869
Citation:
Wu, Y, Yuan L, Guo X, Holding DR, Messing J.  2013.  Mutation in the seed storage protein kafirin creates a high-value food trait in sorghum. Nat Commun. 4:2217.