Research Overview

The control of growth is a fundamental, yet poorly understood, aspect of development. What dictates the size of a particular organ (e.g., how does a hand or a heart "know" how large it should be) or a particular organism (e.g., why is a mouse small and an elephant large)? Decades ago, regeneration experiments revealed an intimate relationship between organ patterning and organ growth, but the molecular basis for this relationship has remained elusive.