Severinov Lab

Researchers unlock new CRISPR system for targeting RNA

Discovered in bacteria as viral defense mechanism, researchers program C2c2 to manipulate cellular RNA using CRISPR

Dr. Konstantin Severinov Earns $1.2M NIH Grant

The National Institute of General Medical Sciences - as part of the National Institutes of Health has awarded $1,200,000 to Dr. Konstantin Severinov, Principal Investigator at the Waksman Institute in support of his latest research project to increase understanding of bacterial immunity and help to design new compounds that inhibit small RNA-based adaptive bacterial immunity, a validated target of antibiotics.

Dr. Konstantin Severinov

Principal Investigator

Understanding RNA polymerase (RNAP) structure and function is a key to understanding gene expression in molecular detail. The long-term objective of our research is to uncover the molecular basis of transcription mechanism and regulation through structure-functional analysis of bacterial RNAP and associated proteins. In addition, we use bacteriophage development as a model system to study temporal regulation of gene expression and to uncover novel mechanisms of transcription regulation. We also study microcins, small ribosomally-synthesized inhibitors of bacterial growth.