Modulators of Notch signaling
.
1998.
Journal:
Seminars in Cell & Developmental BiologyVolume Number:
9Pages:
609-17Abstract:
In addition to the core components of the Notch pathway, a number of proteins have been identified that exert positive or negative influences on Notch signaling. These include extracellular modulators, which may influence binding or activation of Notch by its ligands, cytoplasmic modulators, which presumably influence signal transduction steps after receptor activation, and nuclear modulators, which may influence the transcriptional activity of a Notch-CSL protein complex. Many of the cytoplasmic and nuclear modulators appear to bind directly to discrete domains within the intracellular domain of Notch. Genetic studies indicate that distinct modulators are deployed during distinct modes of Notch signaling.
Related External URL:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9892565- Citation:
- Panin, VM, Irvine KD. 1998. Modulators of Notch signaling. Seminars in Cell & Developmental Biology. 9:609-17.
Dr. Kenneth D. Irvine
Principal Investigator
